Arzoo Prasai
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital , Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.
Qianzi Kou
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital, Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.
Ying Li
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital, Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.
Vicheth Virak
Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern Medical University, No. 253, Middle Gongye Avenue, Haizhu District, Guangzhou 510282, Guangdong, The People’s Republic of China
Sokheng Phal
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Nora Iv
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Rattanaricky Ung
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Sokhuon Cheat
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Gechhorng Lim
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Vahid Say
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Ratanak Pich
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Seng An Hong
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Nita Nouth
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Dinarong Phan
School of International Education, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Pengkhun Nov
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital of Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.";}
Juanli Xu
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital of Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.
Jiqiang Li
Department of Radiation Oncology，Oncology Center, Zhujiang Hospital of Southern Medical University, No.253 Mid Gongye Ave, Haizhu District, Guangzhou, Guangdong Province, Postal code 510282, China.
Abstract
Abstract
Background: Colorectal cancer (CRC) represents a significant health issue globally, and comprehending it’s molecular basis is crucial for developing effective intervention strategies. This research explores the causal links among cytokines, and CRC through a Mendelian Randomization (MR) framework.
Methods: A comprehensive two-sample Mendelian randomization (MR) analysis was performed in this research. In summary, publicly accessible genetic data were used to explore the causal relationship between 41 cytokines, 91 cytokines and with colorectal cancer (CRC). For MR analysis, the inverse variance weighted (IVW) method and weighted medians were applied, while to evaluate heterogeneity and pleiotropy, sensitivity analyses were performed.
Results: Our results demonstrated a significant association between the likelihood of developing of colorectal cancer (CRC) and the concentration of the T-cell surface membrane glycoprotein CD5 [odds ratio (OR) = 0.746, 95% confidence interval (CI) = 0.605–0.920, p = 0.006], C-C motif chemokine 4 [OR = 0.886, 95% CI = 0.810–0.969, p = 0.008], CUB domain-containing protein 1 [OR = 0.845, 95% CI = 0.738–0.968, p = 0.0157], TNF-related apoptosis-inducing ligand [OR = 0.858, 95% CI = 0.755–0.975, p = 0.018], Interleukin-6 [OR = 0.719, 95% CI = 0.570–0.9058, p = 0.005], and Tumor necrosis factor beta [OR = 1.102, 95% CI = 1.015–1.197, p = 0.019].
Conclusion: These findings open new avenues for additional research into the clinical use of T-cell surface membrane glycoprotein CD5, C-C motif chemokine 4, CUB domain-containing protein 1, TNF-related apoptosis-inducing ligand, Interleukin-6, and Tumor necrosis factor beta in colorectal cancer, presenting hopeful opportunities for diagnosis and therapy.
