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Duanyu Wang Syphanna Sou Minghao Tan Virak Vichet Socheat Touch Pengkhun Nov

Abstract

Abstract:


Background: Tracheal, bronchial, and lung cancer (TBL cancer) is the leading cause of cancer mortality in numerous Asian countries, we analyzed time-based trends in the disease burden of TBL cancer, as well as its associated risk factors, in China, Japan, and Southeast Asia.


Methods: We first obtained TBL cancer data from the 2021 Global Burden of Disease Study. We then investigated longitudinal trends in TBL cancer disease burden in China, Japan, and Southeast Asia from 1990 to 2021 by calculating estimated annual percentage change (EAPC) values through linear regression modeling. We next used an autoregressive integrated moving average (ARIMA) model to predict future disease burden (for 2022-2050). Finally, we analyzed risk factors for TBL cancer.


结果: 2021 年,中国 (95% UI:652636-987795)、日本 92119 例 (95% UI:78912-98959) 和东南亚 134949 例 (95% UI:110670-155974) 814364 例。1990 年至 2021 年期间,ASDR (EAPC: 0.42 (95% UI: 0.25-0.6)) 和年龄标准化残疾调整生命年 (DALYs;EAPC: 中国 TBL 癌症的 0.07 (95% UI: -0.08-0.21)) 增加,但日本和东南亚均有所下降。在这些地区,男性的 TBL 疾病负担仍然比女性大得多。这三个地区 TBL 癌症的主要危险因素都是吸烟,但随着时间的推移,吸烟导致的风险比例逐渐降低,与空气污染相关的其他危险因素比例逐渐增加。


结论:在过去的 30 年里,TBL 癌症的疾病负担在日本和东南亚总体上呈下降趋势,但在中国总体上呈上升趋势。在此期间,导致 TBL 癌症的主要危险因素的组成也发生了显着变化,这意味着需要采取更有效的努力来减轻 TBL 的负担,改善治疗,并帮助实现每个地区的公共卫生和发展目标。

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Section
Medical Research-Current Science

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