Evaluation for antidiabetic activities of flavonoids

Abstract

This study aims to evaluate the effects on antidiabetic activities of petroleum

ether extract (SMPE), ethyl acetate extract (SMAE), and flavonoids isolated from

Syzygium malaccense. The results discovered compounds 2, 5, 7, and 9 exhibited

weak inhibitory activity against α-glucosidase with percent inhibition rate of

2.74±0.26 ~ 10.20±0.33 at 1.00×10 -6 mol/L and 9 showed weak promotion on glucose

consumption in HepG2 cells with consumption rate of 4.03±2.70 % at 1.00×10 -6

mol/L. All compounds were firstly tested their HepG2 cells glucose consumption

activities, and 6 and 8 ~ 10 were the first report on their α-glucosidase inhibitory

effect. This research provided new evidences for antihyperglycemic activity of S.

malaccense.