Prognostic marker PARP11 in head and neck squamous cell carcinoma and its relationship with immune infiltration

Abstract

Abstract:

Head and neck squamous cell carcinoma (HNSC) is one of the most common malignancies, and identification of HNSC biomarkers is critical. Polyadenosine 5'-diphosphate (ADP)-ribose polymerase (PARP) 11 is a member of the PARP family. The role of PARP11 in HNSC is unclear. The purpose of this article is to investigate the expression and prognostic value of PARP11 in HNSC patients, its potential biological functions, and its impact on the immune system. Gene expression and clinicopathological analysis, enrichment analysis, and immune infiltration analysis were based on The Cancer Genome Atlas (TCGA) data with additional bioinformatics analysis. Statistical analysis was performed using TIMER and ssGSEA to analyze the immune response to PARP11 expression in HNSCs. In addition, K-M survival analysis and data from HPA were used to validate the results. PARP11 played a vital role as an independent prognostic factor in HNSC patients. PARP11 expression correlated with age, stage, grade, and tumor status. GSEA found that PARP11 is closely related to cell adhesion, receptors, ribosomes, keratinization, and other functions. PARP11 expression was positively correlated with infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, dendritic cells, and neutrophils and was co-expressed with immune-related genes and immune checkpoints. The expression of PARP11 is increased in HNSC, and the high expression of PARP11 is associated with a poor prognosis. PARP11 may affect tumor development by regulating tumor-infiltrating cells in the tumor microenvironment (TME). PARP11 may be a potential target for immunotherapy.