Synthesis and Characterization of 1,2,4-Triazolo [3,4-B] [1,3,4]-Thiadiazole Derivatives as Potent Antimicrobial Agent

Abstract

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. The heterocyclic nucleus 1,2,4-triazolo [3,4-b] [1,3,4]-thiadiazole derivatives constitutes an important class of compounds development. New drug synthesis of novel 1,2,4-triazolo [3,4-b][1,3,4]-thiadiazol derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. Different 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were prepared by condensation of 4- amino-5-(2-(4-isobutyl phenyl) propyl)-4H-1,2,4-triazole-3-thiol (4) with acetic acid and substituted aromatic acids through a one-pot reaction. These compounds were investigated for their antimicrobial activity. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains.