Research Progress on the Mechanism of Acupuncture Intervention in Migraine Headache Based on PI3K/Akt and NF-κB Signaling Pathways

Abstract

Migraine Headache is clinically characterized primarily by unilateral or bilateral headache, frequently accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia, significantly impairing patients' quality of life and work efficiency. Acupuncture, as a crucial therapeutic approach in clinical practice, has been widely applied and demonstrates established efficacy. The phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways play pivotal roles in the mechanisms underlying acupuncture treatment for MH. Based on the PI3K/Akt and NF-κB signaling pathways, this review systematically summarizes the research progress on the mechanism of action of acupuncture in treating MH, aiming to provide novel perspectives and approaches for future research and clinical practice.