A Case of Myelinating Oligodendrocyte Glycoprotein Antibody-associated Optic Neuritis (MOG-ON)

Abstract

Myelinating oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) is a rare demyelinating disease of the optic nerve prone to clinical misdiagnosis and underdiagnosis, the uniqueness of which is that the patient exhibited a sudden onset of severe vision loss and ocular pain. We report a case of MOG-ON, which was confirmed by antibody testing. The patient, a 37-year-old female, presented with visual loss in the right eye and ocular pain of 4 days' duration. Optical coherence tomography (OCT) showed that the right optic nerve head was edematous. 

 The serum MOG antibody was 1:10. Prednisone treatment was administered, and visual acuity improved significantly after 1 week, and returned to normal at 3 months' follow-up. By reporting this case in detail, we hope to improve clinicians' understanding of MOG-ON and optimize the diagnosis and treatment plan.