Cognitive Behavioral Differences in Depression between Organic and Non-Organic Epilepsy Comorbid: An Review

Abstract

Epilepsy-Depression Comorbidity (EDC) is an important challenge in clinical treatment,and there are significant differences in intervention strategies between organic epilepsy and non-organic epilepsy.This article reviews the differences in the efficacy of cognitive behavioral therapy (CBT) and its derivatives (such as mindfulness therapy and digital intervention) in treating depression associated with two types of epilepsy. Studies have shown that CBT has a short-term seizure control rate of 50%-100% for non-organic epilepsy (such as psychogenic non-epileptic seizures),but has no direct effect on the frequency of organic seizures; while depression symptoms are significantly improved in both groups of patients. Digital CBT (e.g. Wellbeing courses) is comparable to traditional treatments, but long-term efficacy remains to be verified.In the future, multicenter randomized controlled trials should be carried out to optimize personalized intervention strategies in combination with biomarkers. Early psychological intervention and establishment of comprehensive evaluation system are the key directions to improve prognosis.