Rare High-Grade Malignant Myxofibrosarcoma and Postoperative Recurrence: A Case Report

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Published May 18, 2025
DOI https://doi.org/10.52845/CS/2025-5-3-29

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Wang Xin
The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou, Gansu Province, China, 730050
Ma Chenghu
School of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730030
Li Jiahuan
The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou, Gansu Province, China, 730050
Tang Qian
The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou, Gansu Province, China, 730050
Wang Jianing
The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou, Gansu Province, China, 730050
Song Mei
Department of Plateau Medicine, The 940th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Lanzhou, Gansu Province, China, 730050

Abstract

本文报告一例罕见的位于左大腿近端高度恶性黏液纤维肉瘤 (MFS) 及其术后复发。黏液纤维肉瘤是软组织肉瘤的一种相对罕见的亚型，高级别的变异非常罕见。患者在手术切除后经历复发。对复发机制的研究表明，肿瘤细胞的侵袭性，支持性肿瘤微环境 (TME) 和癌症干细胞 (csc) 的存在可能是导致复发的关键因素。肿瘤细胞分泌蛋白酶如基质金属蛋白酶 (mmp) 以降解细胞外基质 (ECM)，促进侵袭和转移。TME内的免疫细胞和成纤维细胞为肿瘤存活和生长提供有利条件。具有自我更新和多分化能力的csc允许残留细胞在手术后持续存在和增殖。对这些机制的深入了解对于优化治疗策略和提高MFS患者的生存率至关重要。

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Issue
Vol. 5 No. 3 (2025): Current Science
Section
Medical Research-Current Science