Jiawen Wang
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Mengzhen Yuan
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Yi Zou
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Yue Yu
Deji Pharmaceutical Technology (Tianjin) Co., Ltd
JiaJia Yu
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jiang Liu
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Peng Yu
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Zhen Liu
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Cen Xiang
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
YuOu Teng
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Abstract
Metabolic dysfunction-associated steatohepatitis（MASH） is a common liver disease worldwide and can develop into liver cirrhosis and liver cancer. Current treatment is limited, and the only drug Rezdiffra has limited effects. GFT-505 performed well as a PPAR agonist in stage II, but not as expected in stage III. We replaced the sulfur atom of GFT-505 with selenium to obtain compound 4c. Study evaluating the effect of 4c on the MASH mouse model induced by MCD. The results showed that 4c improved MASH through multi-target synergy and reduced TG and ALT better than GFT-505. This finding provides a theoretical basis and new ideas for the development of novel multi-target anti-MASH drugs.
