The Research Progress of T Lymphocytes in Myocardial Infarction.

Abstract

Myocardial infarction is a severe clinical manifestation of acute coronary syndrome. Despite advancements in early treatment, the long-term impact of ischemia-related heart damage remains a major cause of heart failure. The immune response plays a role in cardiac complications following myocardial infarction. T lymphocytes exhibit different phenotypes after myocardial infarction. CD4⁺ T cells differentiate into multiple subsets, contributing to immune regulation, promoting angiogenesis, regulating scar formation, and influencing cardiac remodeling. CD8⁺ T cells are primarily cytotoxic and may directly kill cardiomyocytes, promoting adverse ventricular remodeling in myocardial infarction. Understanding the role of T cells at each stage of myocardial infarction could identify potential targets for developing new treatments.