Research Progress on the Regulation of Tumor EMT by Dynamic Histone Methylation Modifications

Abstract

Dynamic histone methylation modifications play a crucial role in regulating gene expression and various biological processes, particularly in tumor initiation and progression. These modifications are primarily achieved through the action of histone methyltransferases and demethylases. A key process in cancer development and progression is epithelial-mesenchymal transition (EMT). However, the regulatory role of dynamic histone methylation modifications in tumor EMT has not yet been fully elucidated. This review elaborates on the role of dynamic histone methylation and demethylation modifications in tumor EMT. Additionally, it summarizes the involvement of related modifying enzymes in cancer therapy.